摘要
目的:以莪术醇含量为响应指标,优化莪术有效成分的超临界CO2萃取工艺。方法:通过均匀试验设计,采用气相色谱法测定莪术醇的含量,采用逐步非线性回归、通径分析和等高线图优化提取工艺。结果:莪术的超临界CO2最佳萃取工艺为萃取温度40℃、萃取压力20 MPa、动态萃取时间120 m in、改性剂用量24 mL、改性剂浓度70%、静态萃取时间20 m in;模型预测值的绝对误差小于2%。结论:回归模型极为显著,并且具有很高的预测精度,可以很好对试验结果进行预测。
AIM: To optimize the extraction process for the active components in Curcuma by supercritieal CO2 as guided by the contents of eureumol in Curcuma. METHODS: Gas chromatography was used to determine the contents of cureumol in the extract. Uniform design and path analysis were used to optimize SFE process. RESULTS: The optimum process was established as following:20 MPa as extracting pressure, 40℃ as extracting temperature, 120 minutes as dynamic extracting time and 20 minutes as static extracting time, 24 mL of 70% alcohol as modifier. The absolute error of tile predicted value from the model was smaller than 0.6%. CONCLUSION: The regression model is very notable and reasonable and can forecast results precisely.
出处
《中成药》
CAS
CSCD
北大核心
2006年第3期325-328,共4页
Chinese Traditional Patent Medicine
关键词
超临界萃取
莪术醇
均匀设计
回归分析
通径分析
supercritical extraction
curcumol
unifoml design
regression analysis
path analysis