盐酸丁咯地尔治疗血管性痴呆的临床研究

Effects of buflomedil on vascular dementia

目的观察盐酸丁咯地尔治疗血管性痴呆的临床疗效和对生活质量的影响。方法将64例血管性痴呆患者随机分为丁咯地尔治疗组和对照组各32例,治疗组给予丁咯地尔150 -200 mg,对照组给予胞二磷胆碱750 mg,均每日1次静脉滴注,20 d为1个疗程,两组其他治疗均相同。治疗前后评价简易智能精神状态评估量表(MMSE)、日常生活功能量表(ADL)、长谷川痴呆量表(HDS)、痴呆严重程度临床评定量表(WMS)及血液流变学的变化。结果治疗组用药后 MMSE(22．43±3．03)分、ADL(24．43±8．72)分、HDS(23．41±2．81)分、WMS(70．34±18．45)分较对照组MMSE(20．58±3．81)分、ADL(29．23±14．36)分、HDS(20．34±6．24)分、WMS(60．15± 22．49)分明显改善,差异有统计学意义(P<0．05或P<0．01)。结论盐酸丁咯地尔可明显改善血管性痴呆的智能状态、认知功能及提高生活质量,其可能通过抑制血小板聚集而发挥作用。

Objective To observe the effect of buflomedil on patients with vascular dementia. Methods Sixty- four patients with vascular dementia were randomly divided into two groups . The buflomedil group of 32 patients was treated with buflomedil 150 - 200 rag, once a day for 20 days. The control group of 32 patients was treated with citicolinum 750mg, once a day for 20 days. Then their MMSE, ADL, HDS and WMS were evaluated and the hemorheologic indexes were.measured in both groups before and after treatment, respectively. Results In buflomedil group the scores of MMSE, ADL, HDS and WMS were （22.43 ± 3.03 ） score, （24.43 ± 8.72） score, （23.41 ± 2.81 ） score, （70.34± 18.45） score as that were（20.58 ± 3.81） score, （29.23 ± 14.36） score, （20.34 ± 6.24） score, （60.15 ± 22.49） score in control group. There was significant difference between the two groups（P〈 0.05 or P 〈 0.01）. Conclusions The buflomedil is good for functional recovery in vascular dementia patients by means of inhibiting platelet activity.