摘要
阿尔茨海默病(AD)是最常见的痴呆性疾病,研究者一直在寻找用于该病确定诊断的血浆或血清生物标志物。该文对与AD主要病理过程如淀粉样蛋白斑形成、炎症反应、氧化应激、脂质代谢和血管病变等相关的一些血浆生物标志物的研究进展作一综述。
出处
《国际检验医学杂志》
CAS
2006年第3期267-269,共3页
International Journal of Laboratory Medicine
参考文献19
-
1Solfrizzi V,Panza F,D'Introno A,et al.Lipoprotein(a),apolipoprotein E genotype,and risk of Alzheimer's disease.J Neurol Neurosurg Psychiatry,2002,72(6):732-736.
-
2Fukumoto H,Tennis M,Locascio JJ,et al.Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels.Arch Neurol,2003,60(7):958-964.
-
3Mayeux R,Honig LS,Tang MX,et al.Plasma A[beta]40 and A[beta]42 and Alzheimer's disease:relation to age,mortality,and risk.Neurology,2003,61(9):1185-1190.
-
4Hock C,Konietzko U,Streffer JR,et al.Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.Neuron,2003,38(4):547-554.
-
5Orgogozo JM,Gilman S,Dartigues JF,et al.Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization.Neurology,2003,61(1):46-54.
-
6Padovani A,Borroni B,Colciaghi F,et al.Abnormalities in the pattern of platelet amyloid precursor protein forms in patients with mild cognitive impairment and Alzheimer disease.Arch Neurol,2002,59(1):71-75.
-
7Baskin F,Rosenberg RN,Fang X,et al.Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients.Neurology,2003,60(12):2006-2007.
-
8Borroni B,Colciaghi F,Lenzi GL,et al.High cholesterol affects platelet APP processing in controls and in AD patients.Neurobiol Aging,2003,24(5):631-636.
-
9Dufouil C,Richard F,Fiévet N,et al.APOE genotype,cholesterol level,lipid-lowering treatment,and dementia.Neurology,2005,64(9):1531-1538.
-
10Tan ZS,Seshadri S,Beiser A,et al.Plasma total cholesterol level as a risk factor for Alzheimer disease:the Framingham Study.Arch Intern Med,2003,163(9):1053-1057.
同被引文献21
-
1许琴华,曹非.Alzheimer病生物标志物表达的研究进展[J].现代生物医学进展,2006,6(9):102-104. 被引量：4
-
2Blennow K. Cerebrospinal Fluid Protein Biomarkers for Alzhei- mer's Disease[J]. NeuroRx, 2004,1 (2) : 213-225.
-
3Hulstaert F, Blennow K, Ivanoiu A, et al. Improved discrimination of AD patients using beta-amyloid (1-42) and tau levels in CSF [J]. Neurology, 1999,52(8) : 1555-1562.
-
4Mattsson N,Zetterberg H, Hansson O,et al. CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impair- ment[J]. Journal of the American Medical Association, 2009,302 (4) :385-393.
-
5Sjogren M,Vanderstichele H,Agren H,et al. Tau and Abeta42 in eerebrospinal fluid from healthy adults 21-93 years of age: estab- lishment of reference values[J]. Clin Chem, 2001,47 ( 10 ): 1776- 1781.
-
6Mattsson N,Zetterberg H,Hansson O,et al. CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impair ment[J]. Journal of the American Medical Association, 2009,302 (4) :385 -393.
-
7Hansson O, Zetterberg H, Buchhave P, et al. Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment;a follow-up study[J]. Lancet Neurolo- gy,2006,5(3) :228-234.
-
8Fagan AM, Roe CM, Xiong C, et al. Cerebrospinal fluid tau/beta- amyloid(42) ratio as a prediction of cognitive decline in nonde- mented older adults[J]. Arch Neurol, 2007,64 (3) : 343-349.
-
9Bouwman FH, Vander-Flier WM, Schoonenboom NS, et al. Use- fulness of longitudinal measurements of beta-amyloid 1-42 in cere- brospinal fluid of patients with various cognitive and neurologic disorders[J]. Clin Chem,2006,52(8) : 1604-1606.
-
10Mulugeta E,Londos E,Ballard C, et al. CSF amyloid beta38 as a novel diagnostic marker for dementia with Lewy bodies[J]. Neu- rol Neurosurg Psyehiatr,2010,82(2) :160-164.
-
1德田隆彦,欧阳嶷.’99一年中内科学的进展专辑(三)──神经疾病[J].日本医学介绍,2000,21(9):391-396.
-
2陈薇,李小明,胡汉宁,涂建成.老年性痴呆患者血浆同型半胱氨酸、镁离子水平变化及与年龄的相关性分析[J].微循环学杂志,2012,22(3):44-46. 被引量：13
-
3罗浩,李闻文,周军.脑内补体系统与阿尔茨海默病[J].中国免疫学杂志,2012,28(12):1146-1149. 被引量：4
-
4陈锐,罗学娅,于新宇,刘庆平.血管性痴呆及其高危因素和药物治疗研究进展[J].新医学,2012,43(6):433-436. 被引量：10
-
5胡沛霖.高血压脑出血血肿液IL-6与TNF-α水平及其临床意义[J].中国神经免疫学和神经病学杂志,2006,13(1):66-66. 被引量：15
-
6韩辉,靳轶敏,付君,乔芳芳.高同型半胱氨酸血症与缺血性脑血管病的关系[J].中国危重病急救医学,2004,16(3):188-189. 被引量：11
-
7付剑亮.血管性痴呆，预防胜于治疗[J].家庭用药,2016,0(9):31-31.
-
8Haines JL,徐宏斌.老年性痴呆性疾病的遗传学——一个疑难问题[J].国外医学（遗传学分册）,1992,15(4):191-193.
-
9曲松滨,徐岩松,王峰.脑出血患者急性期血浆或血清中7种神经肽含量变化的观察[J].中国危重病急救医学,2000,12(12):717-719. 被引量：4
-
10韩丁,王琼,王振福.路易体痴呆的研究进展[J].中华医学杂志,2013,93(25):2010-2012. 被引量：1
