复方清肝汤对小鼠急性酒精性肝损伤的保护作用的研究

Study on the Protective Effect of Compound Qingan Decoction on Rat Acute Alcoholic Liver Wound

目的:探讨复方清肝汤对小鼠急性酒精性肝损伤的保护作用。方法:以白酒灌胃法制作小鼠急性肝损伤模型,观察血清丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)活性和肝匀浆中谷胱甘肽(GSH)、丙二醛(MDA)含量、肝脏病理形态学变化。结果:复方清肝汤组10g/kg、20g/kg使血清ALT、AST活性和肝匀浆MDA含量显著降低,肝匀浆GSH含量显著升高,肝脏病理损伤明显减轻。结论:复方清肝汤对酒精性肝损伤有保护作用。

Objective： To investigate the protective effect of compound qingan decoction on rat acute alcoholic liver wound. Method： The model of liver wound was prepared with distillate spirit administration by gavage, to observe the activity of ALT, AST and the content GSH, MDA in liver homogenate and liver change of pathomorphism. Result： at the compound qingan decoction group（ 10g/ kg, 20g/kg）, the activity of ALT, AST and the content of MDA in liver homogenate cut down distinctly, the content of GSH stepped up distinctly, the liver pathology wound relieved obviously. Conclusion： Compound qingan decoction has protective effect on alcoholic liver wound.