伍用纳络酮治疗新生儿缺氧缺血性脑病20例疗效观察

目的探讨伍用纳络酮治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法将36例HIE患儿分为两组,观察组20例在常规治疗的基础上加用纳络酮静脉滴注,对照组16例仅用常规治疗。结果观察组临床疗效显效率65.00%,总有效率90.00%;对照组分别为25.00%及56.25%,两组比较差异有显著性(P<0.01)。观察组临床症状、体征全部消失时间(5.84±2.76日)较对照组(10.02±3.28日)明显缩短(P<0.01)。结论伍用纳络酮治疗新生儿缺氧缺血性脑病疗效明显优于常规治疗。

Objective To evaluate the clinically curative effects of naloxone on neonates with hypoxia-ischemic encephalopathy （HIE）. Methods 36 cases of neonates with HIE were divided into two groups： The observation group （n=20） based on routine therapy was treated with naloxone injection while controlled group （n=16） treated with routine therapy alone. Results The effective rate was 65.00% and total response rate was 90.00% in observation group but they were 25.00% and 56.25% respectively in controlled group. Comparing between two groups, the differences were significant （both P〈0.01）. The mean time for all of the symptoms and signs to disappear [（5.84±2.76）d] in observation group was significantly shorter than that [（10.02±3.28）d] in controlled group （P〈0.01）. Conclusion The curative effects treated naloxaone on neonates with HIE are significantly superior to those treated with routine therapy.