雷贝拉唑对糜烂性反流性食管炎患者食管内pH影响的对照研究

A Controlled Study of Rabeprazole in the Treatment of Erosive Reflux Esophagitis

目的:了解雷贝拉唑对糜烂性反流性食管炎(RE)患者的疗效及食管内pH的影响。方法:59例经内镜诊断为RE的患者,其中男36例,女23例,平均年龄(37±5.72)岁,随机分为A组及B组,A组患者服用雷贝拉唑10mg,每日一次,共14天;B组患者服用奥美拉唑20mg,每日一次,共14天。结果:A组治疗前食管内pH<4的时间(min)、pH<4的次数、pH<4(%)分别为:120±51、106±70、13±3.2;治疗后则分别为12.58±6、63.33±9.5及1.4±0.2;B组治疗前食管内pH<4的时间(min)、pH<4的次数、pH<4(%)分别为115±66、133±71及15±1.9;治疗后则分别为15.21±11、13.1±10.2及2.9±1.5。两组治疗前后均差别有显著性(P<0.001),两组之间的差别无显著性(P>0.05)。内镜检查的结果表明:两组治疗前后均有显著改善。结论:雷贝拉唑是治疗RE的首选药物,个体差异性较小,其疗效与抑酸效果有关。

Objective. To explore the possible effect of rabeprazole on erosive reflux esophagitis （RE） and its pH. Methods： 59 patients including 36 male and 23 female, mean age of 37±5. 72yr, who were diagnosed as RE by gastroendoscope, were randomly divided into groups A and group B, and treated with Rabeprazole （10mg once daily for 14 days） and Omeprazole （20mg once daily for 14 days） respectively. The results were compared between two groups. Results： In the group A, the continued time in pH〈C4, the pH〈S4 numbers and fraction time of pH〈4（%） was 120±51, 106±70, 13±3. 2 and 12. 58±6,63.33±9. 5, 1.4±0. 2 before and after treatment respectively; in the group B, it was 115±66, 133±71, 15±1.9 and 15. 21±11, 13. 1±10, 2. 9±1.5 before and after treatment respectively. There were significant differences of the time of pH〈4, the pH〈4 numbers and fraction time of pH〈4（%） between group A and group B. The gastroendoscopic examination indicated that the significant improvement of esophageal mucosa was found in both groups. Conclusions： Rabeprazole is the first choice for the treatment of RE and without individual difference; the effect related to the powerful effect of acid inhibition.