盐酸曲马多在玻碳电极上的伏安行为及测定

Anodic voltammetry of tramadol hydrochloride at a glassy carbon electrode

研究了盐酸曲马多在玻碳电极上的伏安行为．在pH=7的BR底液中，用微分脉冲阳极溶出伏安法得到良好的氧化峰，峰电位为0．694V（vs．Ag/AgCl）．峰电流与盐酸曲马多浓度在6×10^-6～1×10^-4mol/L（r=0．9951）范围内呈线性关系，检测限为1．52×10^-6mol/L．采用该方法可不经分离直接测定药物制剂，回收率在95．6％～102．8％．

In a medium of pH = 7 BR, an oxidative peak was obtained for tramadol hydrochloride by differential pulse stripping voltammetry, at about ＋ 0. 694 V（vs. Ag/AgCl）. A liner relationship was held between the peak current and concentration of tramadol hydroch[oride in the range of 6 ×10^-6 1 ×10^-4 mol/L （r = 0. 995 1） with a detection limit of 1.52 ×10^-6 mol/L. The method has been used for the direct determination of tramadol hydrochloride in tablets, the detect recovery is between 95.6% and 102.8%.