异位性皮炎患者血清中可溶性E-selectin及总IgE检测

Study on serum soluble E-selectin and total IgE in patients with atopic dermatitis

目的探讨异位性皮炎(AD)血清标志物间的相互关系。方法应用ELISA法检测了20例异位性皮炎、18例荨麻疹及20例正常对照血清中可溶性E-选择素(sE-selectin)。同时应用不同方法测定了其血清总IgE(tIgE)及嗜酸粒细胞阳离子蛋白(ECP)。结果异位性皮炎sE-selectin及tIgE水平非常显著高于对照组(P<0.001);且sE-selectin与tIgE间具有显著相关性(γ=0.688,P=0.003)。异位性皮炎血清中ECP也有升高。上述血清标志物在治疗后水平降低。结论sE-selectin可能是异位性皮炎严重性及活动性的良好标志物。

Objective In order to explore the mutual relationships of the serum markers in patients with atopic dermatitis （AD） .Methods The serum soluble E-selectin （sE-selectin） from 20 AD, 18 urticaria and 20 normal individuals were detected by ELISA. Serum total IgE（tIgE） and eosinophil cationic protein （ECP） were assayed with the Pharmacia CAP system. Results The levels of sE-selectin and tIgE in AD were higher than in normal control group（ P 〈 0.001. A significant correlation between serum sE-selectin and tIgE was observed among participants（ γ= 0.688, P = 0. 003）. The serum levels of ECP were also elevated in parients with AD.Conclusion sE-selectin may be a good marker for the severity and activity of AD.