雷尼替丁与复方丹参预防应激性溃疡出血的临床观察

Clinical observation on effect of Ranitidine and Composite Salvia Miltiorrhiza in preventing bleeding stress ulcer

目的观察雷尼替丁与复方丹参预防高危人群应激性溃疡出血(SUB)的作用。方法64例高危人群患者随机分为两组,基础治疗相同。治疗组30例,加用雷尼替丁150mg入壶,1日2次,复方丹参16ml入液静点,1日1次,持续7d;对照组34例,加用泰美尼克40mg入生理盐水100ml静点每日2次,共7d。结果治疗组30例,1例发生SUB;对照组34例,2例发生SUB,统计学处理无显著性差异(χ2=0.01,P>0.05)药费治疗组比对照组明显低(雷尼替丁+复方丹参,1人每日,6.92元;泰美尼克,1人每日126.2元)。结论雷尼替丁与复方丹参预防高危人群SUB,有效率高,价格低廉,值得推广和应用。

Objective To study the preventive effects of Ranitidine and composite salvia miltiorrhisa in preventing the Bleeding stress ulcer in the high risky patients. Methods 64 cases of high risky patients were divided into two groups, the cured group had 30 cases who were treated with Ranitidine（300mg/ day） and compositc salvia miltiorrhisa injection （16ml/day） for 7days ; the control group 34 cases who were treated with Pantoprazole Sodium for injecton （80mg/ day） for 7days. Results In treatment group one of the patients developed Bleeding stress ulcer, but in the control group there were 2 cases who developed Bleeding Stress ulcer, （x^2= 0.01, P 〉 0.05）, the price of the treatthent group was 119.28 yuan lower than the control group every day. Conclusion Ranitidine and composite salvia miltiorrhha injection has an advantage over the Pantoprazole Sodium in preventing Bleeding stress ulcer, it is easy to apply in clinical practice.