摘要
目的:探讨肺靶向甲强龙琥珀酸钠明胶微球的制备、稳定性及体外释药特性。方法:采用二步法制备肺靶向甲强龙琥珀酸钠明胶微球,并结合甲强龙琥珀酸钠的水解特性测定其载药量和体外释药特性。结果:制备出吸胀后平均算术粒径(9.9±3.5)μm的微球,515μm的微球占82.7%,载药量20.5%,在pH7.4PBS缓冲液中的释药规律符合Weibull方程,t1/2为43.5min。微球在室温下放置3个月形态及载药量无明显改变。结论:本方法制备的甲强龙琥珀酸钠明胶微球可用于肺靶向治疗。
Objective: To study the preparation techniques, stability and the release profile in vitro of gelatin microspheres (GMS) encapsulated with methylprednisolone sodium succinate (MPS). Methods. Gelatin microspheres of methylprednisolone sodium succinate (MPS-GMS)were prepared by the two-step method, their drug contents which were corrected by the hydrolytic profile of MPS, and their release profile in vitro was studied. Results: The arithmetic mean diameter of MPS-GMS was 9.9±3.5 μm after swelling. There were 82.7% of the microspheres ranging from 5 to 15 μm. The drug content was 20.5%. The release profile in vitro (pH7.4 phoshate buffer) can be described by the Weibull equation. The t1/2 value was 43.5 min. The shape and drug content were stable for three months when stored at room temperature. Conclusion: MPS-GMS can be used for treatment of lung target.
出处
《武汉大学学报(医学版)》
CAS
2006年第2期196-199,共4页
Medical Journal of Wuhan University
基金
湖北省科技攻关计划(编号:2004AA301C24)
关键词
甲强龙琥珀酸钠
明胶微球
肺靶向给药系统
Methylprednisolone Sodium Succinate
Glatin Microspheres
Lung Targeting Drug Delivery System