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弥漫性大B细胞淋巴瘤 被引量:9

Diffuse large B-cell lymphoma
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摘要 弥漫性大B细胞淋巴瘤(DLBCL)是一类异质性的B细胞性恶性淋巴瘤,其组织形态、免疫表型、分子遗传学特点及预后各异。近年来,对DLBCL进行了大量免疫组化和分子生物学研究,并试图对其进一步分型。作者综述DLBCL的形态学、免疫组化、分子生物学特点及与预后的关系。 Diffuse large B-cell lymphoma (DLBCL), the largest category of lymphoma, is a clinically and biologically heterogeneous disease entity. Immunophenotype, tissue microarray and molecular studies underline the extreme heterogeneity of DLBCL and suggest a subclassification of the tumor. This review summarizes the morphological, immunophenotypic, cytogenetic and molecular genetic features of DLBCL relevant to the precise prognostic previsions.
作者 王焱 周晓军
出处 《医学研究生学报》 CAS 2006年第3期277-280,共4页 Journal of Medical Postgraduates
关键词 弥漫性大B细胞淋巴瘤 组织病理学 免疫表型 分子生物学 预后 Diffuse large B-cell lymphoma Histopathology Immunophenotype Molecular genetics Prognosis
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参考文献26

  • 1Anonymous.A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma.The non-Hodgkin's lymphoma classification project[J].Blood,1997,89(11):3909-3918.
  • 2Harris NL,Jaffe ES,Stein H,et al.A revised European-American classification of lymphoid neoplasm:a proposal from the International Lymphoma Study Group[J].Blood,1994,84(5):1361-1392.
  • 3Harris NL,Jaffe ES,Diebold J,et al.The World Health Organization Classification of neoplastic diseases of the haematopoietic and lymphoid tissues:report of the Clinical Advisory Committee Meeting,Airlie House,Virginia,1997[J].Histopathology,2000,36(1):69-86.
  • 4Jaffe ES,Harris NL,Stein H,et al.WHO Classification of tumors.Pathology and genetics of tumors of haematopoietic and lymphoid tissues[M].Lyon:IARC Press,2001:171-180.
  • 5Armitage JO,Weisenburger DD.New approach to classifying non-Hodgkin's lymphomas:clinical features of the major histologic subtypes[J].J Clin Oncol,1998,16(8):2780-2795.
  • 6Diebold J,Anderson JR,Armitage JO,et al.Diffuse large B-cell lymphoma:a clinicopathologic analysis of 444 cases classified according to the update Kiel classification[J].Leuk Lymphoma,2002,43(1):97-104.
  • 7Alizadeh AA,Eisen MB,Davis RE,et al.Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling[J].Nature,2000,403(6769):503-511.
  • 8Rosenwald A,Wright G,Chan WC,et al.The use of molecular profiling to predict survival after chemotherapy for diffuse large B-cell lymphoma[J].N Engl J Med,2002,346(25):1937-1947.
  • 9Wright G,Tan B,Rosenwald A,et al.A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B-cell lymphoma[J].Proc Natl Acad Sci USA,2003,100(17):9991-9996.
  • 10Piris M,Pezella F,Martinez-Montero J,et al.P53 and bcl-2 expression in high-grade B-cell lymphomas:correlation with survival time[J].Br J Cancer,1994,69(2):337-341.

二级参考文献21

  • 1Baens M, Maes B, Steyls A et al. The product of the t(11;18), an API2-MLT fusion, marks nearly haly of gastric MALT type lymphomas without large cell proliferation[J]. Am J Pathol,2000,156(4):1433-1439.
  • 2Ohshima K, Muta H, Kawasaki C et al. Bcl10 expression, rearrangement and mutation in MALT lymphoma:correlation with expression of nuclear factor-kappaB[J]. Int J Oncol, 2001,19(2):283-289.
  • 3Liu H, Ye H,Dogan A et al. T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10[J]. Blood,2001,98(4):1182-1187.
  • 4Sánchez-Beato M,Sánchez-Aguikera A,Piris MA. Cell cycle deregulation in B-cell lymphomas[J]. Blood,2003,101(4):1220-1235.
  • 5Lin K, Sherrington PD, Dennis M et al. Relationship between p53 dysfunction,CD38 expression, and IgVH mutation in chronic lymphocytic leukemia[J]. Blood,2002,100(4):1404-1409.
  • 6Shaffer AL, Yu X, He Y et al. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control[J]. Immunity,2000,13(2):199-212.
  • 7Rosenwald A, Wright G, Chan WC et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma[J]. N Engl J Med,2002,346(25):1937-1947.
  • 8Lossos IS, Jones CD, Warnke R et al. Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma[J]. Blood,2001,98(4):945-951.
  • 9Boxer LM, Dang CV. Translocations involving c-myc and c-myc function[J]. Oncogene,2001,20(40):5595-5610.
  • 10Sherr CJ. The Pezcoller lecture: cancer cell cycles revisited[J]. Cancer Res,2000,60(14):3689-3695.

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