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TREK-1双孔钾通道的功能研究进展

Proceedings of TREK-1, a subtype of tandem-pore-domain potassium channels
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摘要 Tandem-pore-domain potassium channels are a diverse and highly regulated superfamily of channels that are thought to provide baseline regulation of membrane excitability. Of these, TREK are highly expressed in human CNS. TREK can be regulated by both physical and chemical factors. Lately, study on knockout animals suggested that TREK-1 might participate in the process of general anesthesia of some anesthetics. Tandem-pore-domain potassium channels are a diverse and highly regulated superfamily of channels that are thought to provide baseline regulation of membrane excitability. Of these, TREK are highly expressed in human CNS. TREK can be regulated by both physical and chemical factors. Lately, study on knockout animals suggested that TREK-1 might participate in the process of general anesthesia of some anesthetics.
作者 孙丽娜 王晓良
机构地区 中国协和医科大学.中国医学科学院药物研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2006年第4期385-389,共5页 Chinese Pharmacological Bulletin
关键词 双孔钾通道 神经保护 麻醉 调节 tandem-pore-domain potassium channels neuroprotection anesthesia regulation
分类号 R-05 [医药卫生] R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献28

  • 1Franks N P,Honore E.The TREK K2P channels and their role in general anaesthesia and neuroprotection[J].Trends Pharmacol Sci,2004,25(11):601-8.
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  • 10Maingret F,Honore E,Lazdunski M,Patel A J.Molecular basis of the voltage-dependent gating of TREK-1,a mechano-sensitive K+ channel[J].Biochem Biophys Res Commun,2002,292 (2):339-46.

二级参考文献21

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中国药理学通报
2006年 第4期

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