环氧化酶2和血管内皮细胞生长因子在前列腺癌组织中的表达及意义

Expression of Cyclooxygenase-2 and Vascular Endothelial Growth Factor in Human Prostate Cancer and Its Significance

目的:探讨环氧化酶2(COX2)和血管内皮细胞生长因子(VEGF)在前列腺癌中的表达及临床意义。方法:采用免疫组化SP法检测40例前列腺癌和10例良性前列腺增生(BPH)组织中COX2和VEGF的表达。结果:前列腺癌组织中COX2和VEGF的阳性表达均明显高于BPH(P<0.01);COX2和VEGF在前列腺癌中的表达水平与其病理分级和临床分期均呈正相关(P均<0.05);前列腺癌中COX2表达水平和VEGF的表达水平相关(χ2=4.768,P=0.01)。结论:COX2可能诱导VEGF的表达而促进前列腺癌肿瘤血管的生成和侵袭转移。COX2和VEGF是检测前列腺癌的较好分子标志物,可望用于前列腺癌的辅助诊断和预后判断。

Objective： To evaluate expressions of cyclooxygenase-2 （COX-2） and vascular endothelial growth factor（VEGF） in primary prostate cancer and its clinical significance. Methods： Expressions of COX-2 and VEGF were detected by immunohistochemical assay in tissues of 40 prostate cancer and 10 benign prostatic hyperplasia samples. Results： COX-2 and VEGF levels in prostate cancer were much higher than those in BPH. The degrees of cancer malignancy and invasion positively correlated with the expressions of COX-2 and VEGF. COX-2 level positively correlated with VEGF level. Conclusion： The abnormal expression of COX-2 plays an important role in the development of primary prostate cancer. COX-2 and VEGF are good molecular markers of prostate cancer which are hopeful to be used for the assitant diagnosis and the prediction of prognosis of prostate cancer. Natl J Androl,2006,12 （3） ：207- 210