摘要
Several subsets of T-regulatory (Tr) cells with distinct phenotypes and distinct mechanisms of action have been identified. These include Tr type 1 (Trl) cells; Th3 cells, which primarily secrete transforming growth factor (TGF)-β; and CD4^+CD25^+ T cells, which inhibit immune responses through cell to cell contact.1 It has been shown that CD4^+CD25^+ immunoregulatory T cells induced by the blockade of CD154-CD40 pathway are tolerant to alloantigen, resulting in secondary mixed lymphocyte reaction (MLR) hyporesponsiveness in vitro and tolerance to alloantigen in vivo. Previous studies mainly paid attention to CD4^+CD25^+ immunoregulatory T cells induced by CD154-CD40 blockade, but it was unclear whether CD154-CD40 blockade might induce Trl or Tr1-like cells.
Several subsets of T-regulatory (Tr) cells with distinct phenotypes and distinct mechanisms of action have been identified. These include Tr type 1 (Trl) cells; Th3 cells, which primarily secrete transforming growth factor (TGF)-β; and CD4^+CD25^+ T cells, which inhibit immune responses through cell to cell contact.1 It has been shown that CD4^+CD25^+ immunoregulatory T cells induced by the blockade of CD154-CD40 pathway are tolerant to alloantigen, resulting in secondary mixed lymphocyte reaction (MLR) hyporesponsiveness in vitro and tolerance to alloantigen in vivo. Previous studies mainly paid attention to CD4^+CD25^+ immunoregulatory T cells induced by CD154-CD40 blockade, but it was unclear whether CD154-CD40 blockade might induce Trl or Tr1-like cells.