人食管鳞癌组织中促血管生成素-2的表达

Expression of angiopoietin-2 in human esophageal squamous cell carcinoma tissue

目的探讨食管鳞癌及癌旁组织中促血管生成素-2(Ang-2)的表达。方法采用免疫组织化学SP法检测56例食管鳞癌、13例原位癌、11例重度不典型增生和47例食管断端正常鳞状上皮组织中Ang-2的表达。结果Ang-2的表达主要定位于肿瘤细胞的胞浆和胞膜。食管鳞癌、原位癌组织中Ang-2的表达高于食管正常鳞状上皮组织(P<0.01)和癌旁重度不典型增生上皮组织(P<0.05);重度不典型增生上皮组织中Ang-2的表达也高于食管正常鳞状上皮(P<0.01),但食管鳞癌组织和原位癌组织中Ang-2的表达差异无统计学意义(P>0.05)。Ang-2的表达与食管鳞癌的分化程度、浸润深度、有无淋巴结转移无关(P均>0.05)。结论Ang-2的阳性表达是食管癌鳞癌发生的早期事件。

Aim ： To study the relationship between expression of angiopoietin-2 and the occurrence, infiltration, and metastasis of esophageal squamous cell carcinoma. Methods： S-P immunohistochemical method was performed to detect the expression of angiopoietin-2 ;in 56 cases of esophageal squamous cell carcinoma, 13 cases of squamous carcinoma in situ, 11 cases of severe atypical hyperplasia squamous epithelium, and 47 cases of normal esophageal squamous epithelium, Resuits： angiopoietin-2 was mainly localized in cytoplasm and membrane of esophageal squamous cell carcinoma. The expression of angiopoietin-2 was significantly higher in cancer tissue and carcinoma in situ than those in normal epithelium （ P 〈 0.01 ） and severe atypical hyperplasia epithelium（ P 〈 0.05 ）. It was also significantly higher in severe atypical hyperplasia epithelium than that in normal epithelium （ P 〈 0.05 ）, but there was no significant difference between carcinoma in situ and esophageal squamous cell carcinoma （ P 〉 0.05 ）. The expression of angiopoietin-2 was not correlated with the tumour grade.depth of infiltration,and lymphatic metastasis of esophageal squamous cell carcinoms （P〉0.05）.Conclusion：The expression of angiopoietin-2 may be an early event ,and play an important role in the oceurrence of esophageal squamous cell carcinoma.