摘要
目的探讨转化生长因子(TGF-β1)和成纤维细胞生长因子(FGF)在煤工尘肺发生发展中的意义。方法分别采用双抗体夹心ELISA法、ABC-ELISA法测定50例煤工尘肺患者和50例健康对照人群血清TGF-β1、FGF的含量。结果煤工尘肺患者血清TGF-β1、FGF的含量分别为(60.24±17.57)μg/L、(209.72±59.71)ng/L,高于对照组的(42.81±11.01)μg/L和(77.58±52.82)ng/L。Ⅰ期煤工尘肺患者2指标血清水平与Ⅱ、Ⅲ期患者比较,差异无统计学意义(P>0.05)。尘肺患者血清TGF-β1与FGF水平呈正相关(r=0.419,P<0.05)。结论TGF-β1和FGF可能与煤工尘肺的发生发展有关。
Aim: To study the significance of TGF-β1 and FGF in the occurrence and development of coal workers' pneumoconiosis. Methods: The serum level of TGF-β1 and FGF of 50 patients suffering from coal workers'pneumoconiosis and 50 healthy controls were determined using ELISA and ABC-ELISA, respectively. Results: The serum levels of TGF-β1 and FGF of patients were (60.24 ± 17.57) μg/L, (209.72 ± 59.71 ) ng/L, respectively, which were higher than those of the control (42.81 ± 11.01 ) μg/L and (77.58 ± 52.82 ) ng/L. There was no statistical significance between the first stage ,and the second and third stage patients in the serum levels of TGF-β1 and FGF. The serum levels of the two proteins of the patients were positively correlated (r = 0. 419,P 〈 0.05 ). Conclusion: TGF-β1 and FGF may be related to the occurrence and development of coal workers'pneumoconiosis.
出处
《郑州大学学报(医学版)》
CAS
北大核心
2006年第2期376-377,共2页
Journal of Zhengzhou University(Medical Sciences)