血清β淀粉样蛋白含量与年龄关系的研究

Relationship between serum Aβ_(1-28) level and age

目的探讨我国成人血清β淀粉样蛋白(Aβ1-28)含量与年龄之间的关系,为研究Aβ1-28与阿尔茨海默病(AD)的关系奠定基础.方法采用平衡饱和竞争放射免疫分析法,检测智能正常成人人群中血清Aβ1-28含量,其中青年组(20～35岁)l00例、中年组(36～59岁)100例、老年组(60～79岁)100例与高龄老年组(80～94岁)35例.结果青年组、中年组、老年组、高龄老年组血清Aβ1-28含量分别为(0.77±0.16)μg/L、(0.77±0.17)μg/L、(0.68±0.20)μg/L、(0.67±0.25)μg/L.结论我国智能正常成人人群中血清Aβ1-28水平与年龄无直接关系.

Objective To investigate the relationship between serum Aβ1-28 level and age in Chinese adults, and lay the foundation for the study of Aβ1-28 and Alzheimer＇ s disease. Methods With the method of balanced saturated competition radioimmunoassay, we measured serum Aβ1-28 levels in 335 normal mental state adults, who were divided into four groups including yotmg （ n = 100, age of 20 N 35, ）, middle aged adults （ n = 100, age of 36-59）, old （ n = 100,age of 60-79） and very old aged （ n =35, age of 80- 94）.Results The serum Aβ 1-28 level of four groups were （0.77 ± 0.16） μg/L, （0.77 ± 0.17） μg/L, （0.68 ± 0.20） μg/L, and （0.67 ± 0.25） μg/L, respectively. Conclusion There is no direct relation between serum Aβ1-28 level and age in normal mental state adults.