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血清β淀粉样蛋白含量与年龄关系的研究 被引量:1

Relationship between serum Aβ_(1-28) level and age
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摘要 目的探讨我国成人血清β淀粉样蛋白(Aβ1-28)含量与年龄之间的关系,为研究Aβ1-28与阿尔茨海默病(AD)的关系奠定基础.方法采用平衡饱和竞争放射免疫分析法,检测智能正常成人人群中血清Aβ1-28含量,其中青年组(20~35岁)l00例、中年组(36~59岁)100例、老年组(60~79岁)100例与高龄老年组(80~94岁)35例.结果青年组、中年组、老年组、高龄老年组血清Aβ1-28含量分别为(0.77±0.16)μg/L、(0.77±0.17)μg/L、(0.68±0.20)μg/L、(0.67±0.25)μg/L.结论我国智能正常成人人群中血清Aβ1-28水平与年龄无直接关系. Objective To investigate the relationship between serum Aβ1-28 level and age in Chinese adults, and lay the foundation for the study of Aβ1-28 and Alzheimer' s disease. Methods With the method of balanced saturated competition radioimmunoassay, we measured serum Aβ1-28 levels in 335 normal mental state adults, who were divided into four groups including yotmg ( n = 100, age of 20 N 35, ), middle aged adults ( n = 100, age of 36-59), old ( n = 100,age of 60-79) and very old aged ( n =35, age of 80- 94).Results The serum Aβ 1-28 level of four groups were (0.77 ± 0.16) μg/L, (0.77 ± 0.17) μg/L, (0.68 ± 0.20) μg/L, and (0.67 ± 0.25) μg/L, respectively. Conclusion There is no direct relation between serum Aβ1-28 level and age in normal mental state adults.
出处 《中华老年心脑血管病杂志》 CAS 北大核心 2005年第6期398-400,共3页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金 军队"十五"医药科研课题基金(01Q059)
关键词 阿尔茨海默病 淀粉样Β蛋白 年龄因素 放射免疫测定 Alzheimer disease amyloid beta-protein age factors radioimmtmoassay
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