摘要
Aim To study the chemical constituents of seeds of Herpetospermum caudigerum. Methods Column chromatography was used in the isolation procedure, and the structure was elucidated by spectral data, whose pharmacologic activity was assayed in vitro. Results A new compound named herpetin was isolated, whose structure was determined to be 3-benzofuran methanol-2, 3-dihydm-2-（4- hydroxy-3-methoxyphenyl ）-4-methoxy-6-[ tetrahydm-2-（ 3-hydroxy-4-methoxyphenyl ）-3-methanol ]-2- furanmethyl, showed significant inhibitory effects on HBV-DNA and the replication and expression of HBsAg and HBeAg. Conclusion Herpetin offers wide research and development prospect.
目的研究波棱瓜子的化学成分。方法运用柱层析进行分离,对所分得的化合物运用波谱数据进行结构解析,并对其进行体外和体内药效学评价。结果从波棱瓜子中分得了一新化合物,命名为波棱素,化学结构鉴定为:3苯并呋喃甲羟基2,3二氢2(4羟基3甲氧基)苯4甲氧基6(2(3羟基4甲氧基)苯3甲羟基2甲基四氢呋喃).药效学研究表明,波棱素对HBsAg,HBeAg和HBVDNA具有显著的抑制作用。结论波棱素显示了广泛的研究和开发前景。
基金
GreatInnovationFoundationofBeijingMunicipality,China(D0204003040931).
