鼻咽癌后程三维适形放射治疗疗效观察

Preliminary results of late-course 3 dimentional conformal radiotherapy for primary nasopharyngeal carcinoma

目的探讨鼻咽癌后程三维适形放射治疗(3DCRT)的疗效。方法37例鼻咽癌患者入选适形组,行常规放射治疗(36Gy)+后程3DCRT(34￣38Gy),原发灶总剂量70￣74Gy。同期配对法选择37例的常规放疗患者作为常规组。比较两组近期疗效和急性放射反应。结果适形组完全缓解率达100%,常规组86%。适形组口腔黏膜炎、后组脑神经损伤较严重,但与常规组比较差异无统计学意义。两组5年生存率差异无统计学意义。结论鼻咽癌的3DCRT近期疗效较常规放射治疗理想。

Objective To study the outcomes of nasopharyngeal carcinoma treated by late-course 3- dimentional conformal radiotherapy（3DCRT）. Methods 37 primary nasopharyngeal carcinomas were involved into the CRT group. A total dose of 70 Gy to 74 Gy was delivered by using the conventional method （36 Gy） and late-course 3DCRT technique （34 - 38 Gy）. This group was matched with a same number of patients who were treated with conventional method alone （Routing group）. The treatment results and acute toxicity between the two groups were analyzed. Results The complete response （CR） rate of primary tumor was achieved 100 % in CRT group and 86 % in routing group, respectively. The CRT group had severe mucositis and peripheral neuropathy, but the difference was not statistically significant. There was no difference in the overall survival between the two groups. Conclusion Late-course 3DCRT is an effective method in the treatment of primary nasopharyngeal carcinoma.