盐酸特拉唑嗪片在健康人体内的药动学研究

Pharmacokinetics of terazosin in healthy volunteers

目的对盐酸特拉唑嗪片的健康人体药动学进行研究。方法10名健康志愿者单剂量口服盐酸特拉唑嗪片2mg,血药浓度采用HPLC法测定,数据用3P97软件计算药动学参数。结果该制剂的体内过程符合二房室开放模型,主要药动学参数:tmax为(1.29±0.75)h,Cmax为(27.79±7.99)μg·L-1,t1/2α为(1.88±1.10)h,t1/2β为(13.03±4.17)h,AUC∞0为(278.61±61.62)μg·h·L-1。结论盐酸特拉唑嗪吸收快,消除慢,体内符合开放式二室模型。

Objective To study the pharmacokinetics of terazosin in healthy volunteers. Methods The plasma concentrations of terazosin were determined by HPLC in 10 healthy male volunteers after an oral dose of 2mg formulation. Resuits The concentration - time curves of the formulation were fitted into two - compartment open model. The tmax was （ 1.29±0. 75 ） h, Cmax was （27.79 ± 7.99） μg· L^-1 , t1/2a was （ 1.88 ± 1.10） h ,t1/2β was （ 13.03 ± 4.17） h, and AUCo∞ was （278.61 ± 61.62） μg · h · L^-1. Conclusion The absorption of terazosin was rapid, and the elimination was slow after oral administration.