血清CA_(125)水平检测在妇科疾病中的临床应用

Clinical Analysis of Serum CA_(125) in Gynaecology Disease

【目的】探讨血清CA125水平在某些妇科疾病中的升高情况及临床应用价值。【方法】采用电化学免疫发光法检测196例妇科疾病患者与100名正常人血清CA125水平。【结果】血清CA125水平在卵巢癌、卵巢良性肿瘤、子宫肌瘤、子宫腺肌症、盆腔炎有增高,平均值分别为402.65、146.40、57.62、107.50、56.14 kU/L,妇科疾病各组阳性检出率分别为81.03%、19.73%、40.0%、72.73%、35.0%,其中卵巢癌患者血清CA125水平与卵巢良性肿瘤相比,差异具有高度显著性(P<0.01);子宫肌瘤与子宫腺肌症血清CA125水平差异具有显著性(P<0.05)。如以CA125<35 kU/L和CA125<65kU/L为临界值诊断卵巢癌,其特异性分别为80.2%、92.1%,两者具有统计学差异(P<0.05)。【结论】血清CA125水平增高可见于卵巢癌及一些妇科良性疾病;以CA125<65 kU/L为临界值可显著提高卵巢癌诊断特异性;依据血清CA125水平有利于术前鉴别子宫肌瘤与子宫腺肌症。

[Objective] o investigate the clinical value of serum CA125 in Gynaecology diseases. [Methods] Serum CA125 levels were detected and retrospectively analyzed by electrochemistry-immunominescence method in 194 patients and 100 normal women, [Results] Level of serum CA125 increased in ovarian cancer, benign ovarian tumor, hysteromyoma, uterine adenomyosis, pelvic inflammation. Detection rates were 81. 03%, 19. 73 % ,40. 0 % ,72.730%, 35.0 % respectively and there were statistically significant differences in serum CA125 level between benign ovarian tumor and ovarian cancer（ P 〈20. 01）, between hysteromyoma and uterine adenomyosis（ P 〈20. 05）. There were statistically significant differences in specificity amomg two groups, which were diagnosed as ovarian cancer by critical values of CA125 〈235 kU/L and CA125 〈2 65kU/L, [Conclusion] Lev-l of serum CA125 is abnormal in ovarian cancer and some benign gynaeeology diseases. Hysteromyoma and uterine adenomyosis can be identified easily by it, and specificity of ovarian cancer can be raised by critical value CA125 〈65 kU/L.