摘要
RNA干扰(RNA interference,RNAi)是真核生物中的特异核苷酸序列产生的基因沉默现象,被认为有抑制病毒复制的功能。最近的研究表明,通过诱导RNAi可以抑制多种病毒的复制,包括人类免疫缺陷病毒Ⅰ型,乙型肝炎病毒,丙型肝炎病毒,登革热病毒,脊髓灰质炎病毒,流感病毒,口蹄疫病毒和重症急性呼吸综合征病毒等。总结了目前运用RNA干扰技术抑制病毒复制的研究进展,展望基于RNAi技术的抗病毒治疗的可能性。
RNA interference （RNAi） is a kind of gene silencing phenomenon of the specific nucleotide sequence in eukaryotic organisms, and is oonsidered to have the inhibition capacity of virus replica. Recent studies indicated that through inducement the RNAi could inhibit more viruses to duplicate, including HIV-Ⅰ virus, hepatitis B virus, hepatitis C virus, dengue fever virus, poliovirus, influenza virus, foot-and mouth disease virus, and serious acute respiration syndrome virus etc. The applied development of RNAi technology to inhibit virus replica is summarized, the possibility of antiviral therapy based on the RNAi is prospected.
出处
《微生物学杂志》
CAS
CSCD
2006年第1期66-69,共4页
Journal of Microbiology
基金
国家自然科学基金(30271665)
关键词
RNA干扰
小干扰RNA
病毒
复制
RNA interference
minor interfering RNA
virus replica
