摘要
目的观察预防性应用抗抑郁剂对脑卒中后抑郁(PSD)发生率及神经功能康复的影响。方法64例脑卒中患者随机分成两组,分别接受帕罗西汀与安慰剂治疗,采用改良爱丁堡斯堪的那维亚评分量表(MESS)和日常生活能力量表(ADL)评定脑卒中患者治疗前及治疗后神经功能缺损程度及日常生活能力;治疗结束时评定患者的PSD发生率。结果与安慰剂对照组相比,在治疗结束时,帕罗西汀组患者的MESS、ADL得分分别为11.1±4.3,27.6±4.8,低于安慰剂组的13.6±3.2及32.8±4.1;帕罗西汀组患者的PSD发生率为10.7%,亦低于对照组的41.4%,差异均具有统计学意义。结论预防性应用抗抑郁剂可以降低PSD发生率,并有利于脑卒中患者的神经功能康复。
Objectives： To test whether early prophylactic antidepressant treatment by paroxetine has any beneficial influence on the rate of post-stroke depression （ PSD ） and rehabilitation of stroke patients. Methods： A randomized, placebo controlled study involved 64 consecutive patients admitted to hospital for an acute stroke; they were treated with placebo, paroxetine （20mg/d） respectively. Before and at the end of the observation, we assessed the rate ofPSD and activities of daily living （ADL）, degree of neurological defich {modified Edinburgh-Scandinavia scale,MESS） of all the subjects. Results： At the end of 12-week treatment, the treatment group had lower rate of PSD（ 10. 7% ） than control （ 41.4% ） ; and they had lower score in ADL （ 27. 6±4. 8/32. 8±4. 1 ） and lower score inMESS （11. 1±4. 3/13.6±3. 2） . Conclusion： Prophylactic antidepressant treatment by paroxetine can decrease therate of PSD and improve the neurological function of post-stroke patients.
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2006年第3期186-188,共3页
Chinese Mental Health Journal
基金
辽宁省自然科学基金项目(项目编号:20032110)
关键词
卒中后抑郁
干预研究
抗抑郁剂
预防性治疗
post-stroke depression
intervention study
antidepressant
prophylactic treatment
