补肾活血法对子宫内膜异位症不孕患者外周血TNF、SOD影响

Effect of the Method of Tonifying Kidney and Promoting Blood Circulation on TNF and SOD in Endometriosis-Associated Infertility

目的探讨补肾活血法治疗子宫内膜异位症不孕的作用机理。方法从外周血TNF、SOD水平入手,将子宫内膜异位症(EMT)不孕的患者随机分为中药治疗组30例、对照组15例,分别用中药补肾活血治疗和西药内美通治疗6个月,观察两组的妊娠率和外周血TNF、SOD水平的变化。结果①治疗组的2年累积妊娠率为50%,对照组为33.3%(P>0.05);②治疗组外周血TNF水平治疗前后差异具有显著性意义(P<0.05),对照组治疗前后无显著性差异(P>0.05);③两组外周血SOD水平治疗前后无显著性差异(P>0.05)。结论补肾活血法治疗EMT不孕症与内美通有相近的妊娠率,可能是通过降低外周血TNF水平、提高受孕机能、增加受孕率,而不通过影响外周血SOD水平发生作用。

To assess the mechanism of the method of tonifying the kidney and promoting the blood circulation on endometriosisassociated infertility, this study randomly allocated the patients by pathological examination or laparoseopy or clinic diagnosis to 2 groups, treatment group （30 cases, treated.by Chinese herb in the certain sequence for 6 months ） and control group （15 cases, treated by nemestrane 2.5 mg, two pills once a week, for 6 months ）. Observe the rates of pregnancy and the changes of TNF and SOD detected by RIA in peripheral blood. Results： ① The rate of pregnancy of treatment group in two years was 50%, and was 33.3% in the control group, but the difference was not significant （P〉 0.05）. ② The TNF in peripheral blood of treatment group was （1.11±0.34） ng/ml before treatment and was （1.06±0.33）ng/ml after treatment,but the difference was significant （P〈 0.05）; in the control group, it was （1.31±0.45）ng/ml before the treatment and was （1.21±0.32）ng/ml after treatment（P〉 0.05）.③The SOD in peripheral blood of treat group was （331.80±152.97） ng/ml before treatment and was （345.93±130.70） ng/ml after treatment（P〉 0.05）; in the control group, it was （322.33±107.68） ng/ml before treatment and was （350.01±113.25）ng/ml after treatment（P〉 0.05）. It is suggested that the rate of pregnancy between the treatment group and control group were similar. The Chinese herb could decreased TNF in peripheral and increased pregnancy, but it couldn＇t affect SOD in peripheral blood.