病毒性肝炎患者巨细胞病毒感染115例分析

AnAnalysisofCMVInfectionin115CaseswithViralHepatitis

为分析巨细胞病毒（ＣＭＶ）在病毒性肝炎病人中的流行情况及临床特点，用酶联免疫吸附试验法为６４１１例住院的肝炎病人检测血清抗ＣＭＶ－ＩｇＭ，并对比观察１１５例ＣＭＶ感染者与１９２例ＣＭＶ阴性者的临床症状、体征和肝功能等。结果ＣＭＶ感染率为１．７９％，平均发病年龄３３．６岁，男女比为２．１３∶１，ＣＭＶ与肝炎病毒呈二重、三重、四重感染，感染率分别为４４．７４％、４７．３７％和７．８９％，ＣＭＶ阳性组发热、消化道症状、肝肿大、Ｂ超胆囊改变、丙氨酸转氨酶、天门冬氨酸氨基转移酶、γ－谷酰基转移酶及住院时间均高于或长于ＣＭＶ阴性组。说明ＣＭＶ在各型肝炎中均可存在，大多呈二重或多重感染，并可加重病毒性肝炎的病情。

Tostudyprevalenceofcytomegalovirus(CMV)infectioninpatientswithviralhepati-tisanditsclinicalcharacteristics,serumanti-CMV-IgMwasdetectedin6411hospitalizedhepatitiscases,andclinicalsymptoms,signsandliverfunctionin115caseswithCMVinfectionwerecom-paredwith192casesofnon-CMVinfection.ResultsshowedaCMVinfectionrateof1.79%inthemwithanaverageageof33.6years,asexratioof2.13,anddualsuperinfectionwithCMVandhepati-tisaccountingfor44.74%,andtripleandquadruplesuperinfectionfor47.37%and7.89%,respec-tively.Proportionofthosewithfever,digestivesymptoms,hepatomegaly,changesofgalbladderinultrasoundscan,risingactivitesofserumalanineaminotransferase(ALT),aspartateaminotransfer-ase(AST)andγ-glutamyltransferase(γ-GT)weremore,anddurationofhospitalizationlongerinthecaseswithCMVinfection.ItsuggeststhatCMVcanbefoundinthecaseswithviralhepatitis,mostinaformofdualormultipleinfection,anditcanaggravatehepatitis.