多巴胺D_2受体基因多态性与精神分裂症的关系

ASSOCIATION OF DOPAMINE D2 RECEPTOR GENE POLYMORPHISM WITH SCHIZOPHRENIA

目的：探讨多巴胺Ｄ＿２受体基因多态与精神分裂症的关系。方法：运用人为介入内切酶位点的ＰＣＲ技术，对１０５名精神分裂症患者及１０８名对照成员进行多巴胺Ｄ＿２受体（ＤＲＤ２）基因第３ｌｌ密码子Ｓｅｒ３１１→Ｃｙｓ３ｌｌ错义突变检测。结果：Ｓｅｒ３ｌｌ／Ｃｙｓ３ｌｌ基因型在患病组和对照组中出现比例经统计学检验无显著差异，Ｓｅｒ３１１／Ｃｙｓ３１１占低发病年龄组和有家族史组的比例略高于对照组。结论：ＤＲＤ２基因结构多态性可能与精神分裂症某些亚型相关。

bjective:To explore the relationship between polymorphism of DRD2 and schizophrenia.Methods:105 schizophrenics and 108 controls have been tested on the dopamine D_2 receptor gene using artificial PCR-RFLP method.Results:The distribution of Ser 311/Cys 311 allele had no statistically significant difference between samples and controls.The schizophrenics with Cvs311 tended to have a lower age of onset and a positive family history.Conclusions:The Ser311→Cys311 variant may affectthe onset of some subtypes of schizophrenia.