血清前列腺特异抗原测定及其对前列腺疾病的诊断

DETECTION OF SERUM PROSTATE SPECIFIC ANTIGEN AND ITS APPLICATION IN DIAGNOSING PROSTATOSIS

目的：根据前列腺疾病患者血清前列腺特异抗原（ＰＳＡ）水平，从中筛选前列腺癌，并对各种前列腺疾病进行初步诊断。方法：血清ＰＳＡ水平用酶联免疫法测定。结果：经病理检查证实，癌组ＰＳＡ水平显著高于其余各组；此法筛选前列腺癌敏感度达９１．１８％，特异性为７９．６７％；良性前列腺增生组ＰＳＡ水平随年龄的增加而升高。结论：血清ＰＳＡ可作为筛选前列腺癌的指标，结合临床经直肠指诊、超声诊断及活检，可对疾病做出明确诊断。

Objective. To screen prostate cancer from prostate patients and make preliminary diagnos is of several prostatosis. according to serum prostate specific antigcn ( PSA). Methods . Serum PSA levels were detected by means of Enzyme-linked immunosorbent assay (ELISA). Results. Pathological diag-nosis demonstrated. the serum PSA values of cancer group were significantly higher than those of other groups. PSA as a screening test for prostate cancer. the sensitivity was 91.18%. the specificity was 79. 67%. The PSA level increased with advancing age in the group of benign prostate hyperplasia. Con-clusion. PSA level may be a marker for screening prostate cancer. it can diagnose prostatosis in cooper-ation with digital rectal examination. transrectal ultrasonography.and prostate biopsy.