垂体腺瘤中PTEN蛋白的表达及其临床意义

The expression of PTEN protein in pituitary tumor and its significance

目的:探讨抑癌基因PTEN蛋白在垂体腺瘤中的表达及其与垂体腺瘤侵袭性的关系。方法:应用免疫组化(S-P法)检测59例垂体肿瘤与4例正常脑组织中PTEN蛋白的表达情况。结果:PTEN蛋白在4例正常脑组织中全部表达,非侵袭性垂体腺瘤中PTEN蛋白表达高于侵袭性垂体腺瘤,具有显著性差异(P<0.01),在不同功能类型的垂体腺瘤之间无明显差异(P>0.05)。PTEN蛋白表达在无囊变、卒中垂体腺瘤组中高于有囊变、卒中组,两者有显著性差异(P<0.05)。结论:垂体瘤的发生发展中存在PTEN基因失活现象,并与垂体腺瘤的侵袭性相关。

Objective：To investigate the expression of tumor suppressor gene PTEN protein in pituitary tumor and its clinicopathological significance. Methods：The expression of PTEN protein was detected by immunohistoehemistry（S-P Method ） in 59 cases of pituitary tumor tissues and 4 cases with normal brains. Results：The expression of PTEN protein was significantly stronger in non-invasive pituitary tumor than in invasive pituitary tumor （P〈0.01）,Significants clinical differnce existed between two groups in size, the incidence of hemorrhage ,necrosis and cystic components （P〈0.05）,Conclusions：It is indicated that PTEN gene inactivation may play a role in the genesis and development of pituitary tumor. PTEN protein might serve as a molecular marker to detect the invasive potential of pituitary tumor.