多肽生长因子受体的研究进展

Progress in the Studies of Peptide Growth Factor Receptors

多肽生长因子受体是介导多肽生长因子对细胞的调控作用的膜结合糖蛋白．它们在结构上都可分成胞外区、跨膜区和胞内区三个区段．根据这些区域的结构特点，特别是有无蛋白激酶结构域，提出了新的分类方法；并比较了各类生长因子受体信号转导的异同．

Peptide growth factor receptors are membrane-bound glycopeptides that regulate the action of peptide growth factors on their target cells. Their peptide backbones could be divided into three segments: extracellular region, transmembrane region and intracellular region.According to the structural characteristics in these regions, especially the existence of protein kinase domain in the intracellular region, a new method of peptide growth factor receptors classification is Postulated. The signal transduction pathways of these receptors are also compared.