食管癌组织中S期激酶相关蛋白2mRNA的表达意义

Significance of S-phase kinase-associated protein 2mRNA expression in esophageal carcinoma

目的探讨S期激酶相关蛋白2mRNA在食管癌及其癌旁组织中的表达及其与食管癌临床病理特征的关系.方法采用逆转录-聚合酶链反应(RT-PCR)法检测S期激酶相关蛋白2mRNA在45例手术切除的食管癌组织及癌旁组织中的表达.结果S期激酶相关蛋白2mRNA表达率在食管癌中为66.6%(30/45),而癌旁组织中为24.4%(11/45),差异有显著性(P<0.05).S期激酶相关蛋白2mRNA阳性表达率与患者年龄、性别、肿瘤大小、及有无淋巴结转移无关,与肿瘤分化程度及TNM分期有关(P<0.05).结论S期激酶相关蛋白2的高水平表达促进了食管癌的发生发展.并将可能为食管癌的早期诊断和治疗提供新的手段.

AIM： To explore the S-phase kinase-associated protein 2mRNA expression and its relationship with clinical pathologic characteristics in esophageal cancer. METHODS： The expression of Skp2mRNA in esophageal carcinoma tissues and its corresponding adjacent tissues was detected by RT-PCR in 45 patients. RESULTS： The positive incidence of Skp2mRNA expression in esophageal carcinoma was 66.6%, while in its corresponding adjacent tissues was 24. 4%. The expression of Skp2mRNA was correlated with the degree of differentiation and TNM stage of carcinoma, but not correlated with patient＇s age, gender, tumor size, and lymph node metastasis. CONCLUSION： Increased Skp2mRNA expression contributes to the carcinogenesis and progress of esophageal carcinoma, which may provide some new ways in the early diagnosis and therapy for esophageal carcinoma.