STK15和ki67基因在胃癌组织中的表达研究

Expressions of STK15 and ki67 Gene in Gastric Carcinomas

目的研究丝氨酸/苏氨酸激酶15(STK15)基因在胃癌组织中的表达,及其与临床病理指标以及ki67表达的关系。方法采用免疫组化检测STK15和ki67在89例胃癌组织中的表达。结果STK15在胃癌组织中的表达阳性率为34.83%(31/89),显著高于邻近的非癌组织的4.49%(12/89)(P<0.01);STK15基因过表达与分化型胃癌及其侵润深度密切相关(P<0.05),而与ki67的表达无相关性。结论STK15基因可能在胃癌发生、发展中起相应作用,其过表达程度可作为胃癌的某些生物学行为新的判定指标。

Objective To identify the expression of serine/threonine kinasel5 （STK15） and discuss its relationship with the clinicopathological parameters and ki67 expression in gastric carcinomas. Methods Immunohistochemistry method was used to detect STK15 and ki67 protein level in resected gastric carcinomas in 89 patients. Results The positive rate of STK15 expression in gastric cancer tissue was 34.83% （31/89）, substantially higher than 4.49% （12/89） in adjacent noncancerous tissues （P 〈0.01）. The STK15 overexpression level was closely related to differentiated type gastric cancer and invasion （ P 〈 0. 05） but not to other parameters and ki67 expression. Conclusion STK15 may promote carcinogenesis and cancer development in gastric carcinoma and its overexpression can be a novel marker for identifying certain biological behaviours of gastric cancer.