摘要
从苦木科植物鸦胆子[Brucea javanica(L.)Merr]干躁果实的硅胶干柱柱层析所得的活性部位中经层析分离得到7个四环三萜苦木内酯成份(A,B,C,D,E,F,G),经UV,IR,~1H-NMR,^(13)C-NMR等方法鉴定分别为鸦胆苦醇(Brusatol A),双氢鸦胆苦醇(Dihydrobrusatol,B),鸦胆因B(Bruceine B,C),鸦胆因D(Bruceine D,D),鸦胆因H(Bruceine H,E),鸦胆子甙A(Bruceoside A,F)和双氢鸦胆子甙A(Yadanzioside A,G)。据报道,鸦胆苦醇和鸦胆子甙A具有较强的抗肿瘤活性。
Seven quassinoids were isolated from the active parts obtained by dry-column and chromatography from the treated dry-fruits of Brucea javanica(L. )Merr. and they were identified as Brusatol(A),Dihydrobrusatol(B),Bruceine B(C),Bruceine D(D) ,Bruceine H(E),Bruceoside A(F) and Yadanzioside A(G)by means of UV,IR,1H-NMR, 13C-NMR et. Spectroscopic analysis methods. Brusatol and Bruceoside A are considered as the most significant antitumor components in it.
出处
《天然产物研究与开发》
CAS
CSCD
1996年第2期35-39,共5页
Natural Product Research and Development
关键词
鸦胆子
中草药
抗肿瘤成分
化学成分
B. javanica,tetracyclic triterpene,quassinoids,bruceine