蛋白质分子识别新认识

A Further Realization on the Recognition of Proteins.

近几年，国际上肽库技术得到了迅速的发展，在抗原决定簇的定位及分子识别方面积累了大量的数据．就近３年来蛋白质分子识别方面的观念和认识上的深化进行了综述：ａ．蛋白质间的相互作用是少数几个关键残基的弱相互作用提供了大部分结合能；ｂ．这种相互作用可以用小肽来模拟．因此通过研究小肽片段的特异性相互作用，可以揭示蛋白质间相互作用的本质，为小肽分子药物和疫苗的设计，乃至复杂超分子体系的研究提供了理论基础和实验依据．

The newly developed techniques of peptide libraries have drawn great interest in ligands selection, and also have provided us numerous facts in the fields of molecular recognition. Basing on these results, two new opinions on molecular recognition between macromolecules have been reviewed. First, noncovalent bonds formed between a few residues of two bonded macromolecules may make a major contribution to the total energy of binding. Second, short peptides bearing these critical residues can mimic the interaction of large proteins.Thus, by studying specific Interactions of short peptides, some details of interaction of proteins may be discovered, and also some theoretical and experimental bases to the design of peptidemedicines and vaccines, that may promote the study of supramolecular systems.