C-erbB-2在子宫颈癌中的表达及临床意义

Expression of C-erbB-2 and the Clinical Significance in Cervical Squamous Carcinoma

【目的】探讨癌基因C-erbB-2在子宫颈癌中的表达及与临床病理因素之间的关系。【方法】采用免疫组织化学法检测60例宫颈鳞癌组织,20例宫颈良性肿瘤组织,15例正常宫颈组织中C-erbB-2的表达。【结果】正常宫颈、宫颈良性肿瘤及宫颈鳞癌中C-erbB-2阳性表达率分别为0%,5%,51.66%;三组间差异有显著性(χ2=23.67,P<0.01),在不同分化程度的宫颈鳞癌中,C-erbB-2的表达强度的差异均有显著性(Hc=10.2934;P=0.0058),在不同临床分期的宫颈癌中,C-erbB-2的表达强度差异亦有显著性(Hc=9.2126;P=0.0266),在淋巴结有转移与淋巴结无转移组之间,C-erbB-2的表达强度差异均有显著性(P=0.0010)。【结论】①C-erbB-2的表达与宫颈鳞癌的发生发展有关。②检测C-erbB-2可作为判定宫颈鳞癌恶性程度,评估其侵袭性及转移性的分子生物学指标。其对早期宫颈鳞癌的诊断及宫颈鳞癌的预后判定可能具有重要的参考价值。

[Objective]To study the expression of C-erbB-2 and the clinical significance in cervical squamous carcinoma（CSC）. [Methods]The expression of C-erbB-2 was detected immunohistochemistrically in 60 cases of SCS, 20 cases of eervical benign tumor （CBT） and 15 cases of cervical normal mucosa. [Results]The positive rate of C erbB-2 in CSC, CBT and cervical normal mucosa were 51.66%, 5.00%, 0%, respectively. The expressive rate of C-erbB-2 was significantly different between CSC,CBT and cervical normal mucosa（X^2 = 23.67, P〈0.01）. Among the different histopathological grade groups, the expressive intensity of C-erbB-2 was all significantly different （Hc= 10. 2934 ; P=0. 0058）; among the different clinical stage groups, the expressive intensity of C erbB-2 was also significantly different （Hc= 9. 2126 ; P = 0. 0266） ; between the two groups of lymph node metastasis or not, the expressive intensity of C-erbB-2 was all significantly different （ P ：0. 0010）. [Conclusion]①The expression of C erbB-2 correlates with the oecurrence and development of CSC. ②Detecting the expression of C-erbB-2 may be served as the molecular biologieal index of evaluating infil tration and metastasis, it may be useful for diagnosis of early CSC and evaluating its prognosis.