依托咪酯复合小剂量芬太尼在人工流产术中的应用

Etomidate-Fentanyl Used for Artificial Abortion

【目的】探讨依托咪酯在人工流产术中的安全性。【方法】83例孕妇随机分为依托咪酯(ET组)和依托咪酯-小剂量芬太尼(FET组),观察用药前后血压、心率、SpO2、手术情况、不良反应。【结果】在注药前后两组血压、心率、SpO2变化不明显(P>0.05),两组手术情况无差异,注药部位疼痛ET组多于FET组(P<0.05),注药后肌肉活动ET组多于FET组(P<0.01),术后子宫收缩痛ET组多于FET组(P<0.01)。【结论】在无痛人工流产术中依托咪酯复合小剂量芬太尼较单纯依托咪酯镇痛更有效,副作用少。

[Objective]To study the safety of etomidate used for artificial abortion. [Methods]Eighty three pregnancies were randomly divided into two groups： group ET-etomidate alone and group FET- etomidate plus low-dose fentanyl. The changes of BP, HR and SpO2, were measured before and after injection of medicine. The side effects and the conditions of the operation were observed, [Results]The differences of two groups in BP, HR and SpO2 were insignificant before injection medicine. The pain of injection, the motion of muscle and pain of artificial abortion in FET group were lower than in ET group. [Conclusion]Etomidatc plus low-dose fentanyl offers a useful alternative to etomidate alone with less adverse effect and stronger analgesia for artificial abortion.