小剂量盐酸艾司洛尔对颈丛麻醉时心血管反应的治疗作用

Treatment Effect of Esmolol on Cardiovascular Reactions of Cervical Anesthesia

【目的】观察小剂量盐酸艾司洛尔对颈丛麻醉下甲状腺手术患者心血管反应的平抑作用。【方法】将42例甲状腺手术患者随机分为两组,一组为治疗组(21例),术中一旦患者血压>18.7/12kPa,即静脉注射盐酸艾司洛尔0.5mg/kg;一组为生理盐水对照组(21例)。观察并记录两组患者术中5min、10min、20min时的心率(HR)、收缩压(SBP)、舒张压(DBP)、平均血压(MBP)和血氧饱和度(SpO2)。【结果】盐酸艾司洛尔组术中HR、SBP、DBP及MBP较平稳,术中各项指标比较差异无显著性(P>0.05),未发现心动过缓和低血压的情况。对照组在麻醉后5min、10min、20min时的HR、SBP、DBP及MBP明显升高,差异有显著性(P<0.05或P<0.01)。两组SpO2无明显变化。【结论】静脉注射0.5mg/kg盐酸艾司洛尔治疗颈丛麻醉下甲状腺手术患者的心血管反应安全、有效。

[Objective]To observe the effect of esmolol on cardiovascular reactions of cervical plexus block. [Methods]Forty two cases suffering from hyperthyroidism were divided into two groups at random; group of Esmolol （21 cases） and group of control（21 cases）. If the intraoperative BP〉18.7/12 kPa,esmolo 0.5 mg/kg was used intravenously in esmolol group.saline was used in control group,and then 5-min, 10-min, 20-min heart rate （HR）,systolic pressure （SBP）,diastolic pressure（DBP） and mean blood pressure （MBP） were delected.[Results]The HR, SBP, DBP and MBP were relatively stable in operation of esmolol group. The 5- min, 10-min, 20-min HR, SBP, DBP and MBP were clearly higher after anesthesia in control group than in esmolol group（ P 〈0.05 or P 〈0.01）. [Conclusion]Esmolol is effective and safe on cardiovascular reactions of cervical anesthesia.