降钙素原在细菌感染性疾病诊断中的应用探讨

Investigation of the value of procalcitonin determination in the diagnosis of bacteriosis

目的评价血清降钙素原(PCT)在细菌感染性疾病实验诊断中的价值。方法采用半定量的胶体金免疫结合法,测定35例细菌感染性疾病住院患者及15例非细菌感染性疾病住院患者的PCT,并同期测定患者C-反应蛋白(CRP)与中性粒细胞碱性磷酸酶(NAP)。结果35例细菌感染性疾病患者PCT阳性28例,阳性率80.0%;CRP测定阳性30例,阳性率85.7%,NAP测定阳性26例,阳性率74.3%;同期15例非细菌感染性疾病患者PCT均为阴性,而CRP阳性率66.7%(10/15),NAP阳性率26.7%(4/15)。结论PCT检测应用于细菌感染性疾病,可作为早期快速鉴别细菌感染的实验室新指标。

Objective To evaluate the value of procalcitonin（PCT） determination in the diagnosis of bacteriosis. Methods To determine the serum PCT of 35 patients with bacteriosis and 15 patients with nonbacterial disease by gold immunochromatographic assay（ GICA）, and determine C-reactive protein（CRP） and alkaline phosphatase of neutrophilic granulocyte（NAP） in corresponding period. Results In patients with bacteriosis, the positive rate of PCT, CRP and NAP were 80.0% （28/35）, 85.7% （30/35） and 74.3% （26/35） respectively. However PCT was negative in 15 patients with nonbacterial disease, while the positive rate of CRP and NAP were 66.7% （10/15） and 26.7% （4/15）. Conclusions PCT GICA is an early and rapid new differentiation test fbr bacteriosis.