复发性口疮患者雷公藤多甙治疗前后血清一氧化氮、一氧化氮合酶水平的变化

The change of serum nitric oxide and nitric oxide synthase levels before and after treatment with tripterygium wilfordii glycosides in patient with recurrent aphthous ulcer

目的观察复发性口疮(RAU)患者用雷公藤多甙治疗前后血清一氧化氮(NO)、一氧化氮合酶(NOS)水平的变化,为治疗及预后判断提供依据。方法应用硝酸还原酶法对132例经临床确诊的RAU患者治疗前后和60名正常对照者血清NO、NOS水平分别进行检测。结果在治疗前RAU患者血清NO、NOS水平明显高于正常人,经雷公藤多甙治疗症状缓解或消失后,血清NO、NOS下降至正常人水平,RAU患者治疗前后血清中NO、NOS水平差异有显著性(P<0.01)。结论NO、NOS的动态检测对其疗效判断有一定的价值。

Objective To observe the change of serum nitric oxide（NO） and nitric oxide synthase （NOS） levels in patient with recurrent aphthous ulcer （RAU） before and after treatment with tripterygium wilfordii glycosides （TWG）. Methods The serum levels of NO and NOS in 132 patients with RAU before and after treatment with TWG and 60 healthy controls were detected by nitrate reductase assay. Results The serum levels of NO and NOS in patient with RAU before treatment were higher than those in healthy control. After the treatment with TWG, when the RAU symptom remitted or disappeared the serum NO and NOS dropped to healthy control level, the results showed a significant difference （ P 〈 0.01 ）. Conclusions Monitoring serum levels of NO and NOS is useful to judge the therapeutic effect of TWG on RAU .