腹泻型肠易激综合征脾胃湿热证肠道菌群的变化

Preliminary Study on Intestinal Flora in Diarrhea Type Irrit able Bowel Syndrome with Pi-wei Dampness-heat Syndrome

目的观察腹泻型肠易激综合征脾胃湿热证患者肠道菌群的变化。方法对腹泻型肠易激综合征脾胃湿热证患者(简称脾胃湿热证,21例)粪便中7种常见肠道细菌(肠杆菌、肠球菌、酵母菌、双岐杆菌、乳杆菌、拟杆菌、消化球菌)的分布变化进行观察,并与腹泻型肠易激综合征脾虚证患者(简称脾虚证,22例)及健康人(25名)作对照。结果与健康人比较,脾胃湿热证患者肠杆菌、肠球菌明显增多(P<0.01),双岐杆菌、乳杆菌、消化球菌明显减少(P<0.01);酵母菌、拟杆菌无明显改变。与脾虚证比较,脾胃湿热证患者肠杆菌、肠球菌、双岐杆菌、乳杆菌、拟杆菌、消化球菌明显增多(P<0.05或P<0.01),而酵母菌差异无显著性。结论腹泻型肠易激综合征脾胃湿热证患者存在肠道菌群失调。

Objective To observe the changes of intestinal flora in diarrhea type irritable bowel syndrome with Pi-wei dampness-heat syndrome （IBS-PDS）. Methods The seven kinds of common intestinal bacteria in feces, including enteri bacillus, enterococci, saccharomycete, bifid bacteria, lactobacillus, bacteroides and peptococcus were studied in 21 patients suffered from IBS-PDS, and compared with those in 22 patients with IBS with deficiency of Pi syndrome （DPS） and 25 healthy subjects as control. Results As compared with the healthy subjects, the levels of enteri bacillus and enterococci were significantly increased （P 〈 0.01 ）, the levels of bifid bacteria, Lactobacillus and Peptococcus were significantly decreased （P〈 0.01 ）, and saccharomycete and Bacteroides were insignificantly different in patients with PDS. As compared with patients with DPS, the levels of enteri bacillus, enterococci, bifid bacteria, Lactobacillus, Peptococcus and Bacteroidaceae were significantly increased except the level of saccharomyccte. Conclusion There may be alteration of intestinal flora in patients with IBS-PDS.