膀胱移行细胞癌组织中E-cadherin的表达及与血清CA125检测的关系

Expression of E-cadherin in transitional cell carcinoma of bladder and its relationship with serum CA125

目的探讨膀胱移行细胞癌组织中E-cadherin的表达及其与CA125的关系,以及两者与肿瘤临床特征的关系。方法采用免疫组织化学染色法及放射免疫法检测60例膀胱移行细胞癌标本E-cadherin的表达及血清CA125值,分析表达水平与CA125值的关系。结果E-cadherin正常表达24例(40%),异常表达36例(60%),E-cadherin异常表达率、CA125值随肿瘤临床分期、病理分级的升高而升高(P<0.05);有远处转移者或复发者高于无转移或无复发者(P<0.05),CA125值与E-cadherin的异常表达呈正相关(P<0.01)。结论CA125的检测可作为判断膀胱移行细胞癌恶性程度及预后的指标。

Objective To investigate the expression of E-cadherin and its relationship with serum CA125. Methods Immunohistochemical staining and radioimmunoassay were applied to detect the expression of E-cadherin in 60 cases of transitional cell carcinoma of bladder and the value of serum CA125, and to analyze the relationship between them. Results 34（40%） cases of the expressions of E-cadherin were normal, 36（60%） abnormal. The abnormal expression rate of E-cadherin and the ralue of CA125 rose with the clincal and pathological staging of the carcinoma; the abnormal expression rate of E-cadherin and the value of CA125 of those who had remote metastasis or recurrence of carcinoma were higher than those who had not. The ralue of CA125 was positively related with the abnormal expression of E-cadherin （P〈0. 01）. Conclusion CA125 could act as an indicator of the malignancy and prognosis of transitional cell carcinoma of bladder.