脱水穿心莲内酯二琥珀酸半酯的合成工艺改进

Improved synthesis of dehydroandrographolide succinate

以穿心莲内酯在氮气保护下加入无水吡啶、琥珀酸酐、无水亚硫酸钠，控温在70～80％反应生成炎琥宁（脱水穿心莲内酯二琥珀酸半酯钾钠盐）的重要中间体脱水穿心莲内酯二琥珀酸半酯，总收率为41．7％。操作工序简便，生产成本大大降低，收率高。

Dehydroandrographolide succinate, a key intermediate of potassium sodium dehydroandroan drographolide succinate, was prepared by andrographolide and succinic anhydride,which were protected with nitrogen,in dry pyridine at 70 ～ 80℃ for 2 h using sodium sulfite as reducing agent with yield of 41.7%.