摘要
以穿心莲内酯在氮气保护下加入无水吡啶、琥珀酸酐、无水亚硫酸钠,控温在70~80%反应生成炎琥宁(脱水穿心莲内酯二琥珀酸半酯钾钠盐)的重要中间体脱水穿心莲内酯二琥珀酸半酯,总收率为41.7%。操作工序简便,生产成本大大降低,收率高。
Dehydroandrographolide succinate, a key intermediate of potassium sodium dehydroandroan drographolide succinate, was prepared by andrographolide and succinic anhydride,which were protected with nitrogen,in dry pyridine at 70 ~ 80℃ for 2 h using sodium sulfite as reducing agent with yield of 41.7%.
出处
《安徽医药》
CAS
2006年第3期173-174,共2页
Anhui Medical and Pharmaceutical Journal
关键词
脱水穿心莲内酯二琥珀酸半酯
炎琥宁
工艺改进
dehydmandrographolide succinate
potassium sodium dehydroandroan drographolide succinate
improved synthesis