补肾中药对雷公藤致雌鼠生殖系统损害的保护作用

Protective Effect of Kidney-tonifying Herbal Medicine on the Changes of Female Rat Genital System Induced by Tripterygium wilfordii Hook

目的观察补肾中药拮抗雷公藤对雌鼠生殖系统影响的作用。方法选出具正常性动周期的雌性大鼠30只,随机分为3组:对照组、雷公藤组、复合组(雷公藤+补肾中药),均喂养90d后解剖。结果复合组与雷公藤组比较性动周期完整,雌、孕激素水平增高,雌性生殖器官重量增加,卵巢大,卵泡发育良好,黄体多,血供好;子宫内膜厚,腺体增生;阴道上皮增厚,有角化层。结论补肾中药可拮抗雷公藤致雌鼠生殖系统的毒副作用。

Objective To observe the effect of kidney -tonifying herbal medicine （KTHM） on the changes of female rat genital system induced by Tripterygium wilfordii Hook （TWH）. Methods Thirty temale rats with normal oestrus cycle were randomly divided into 3 groups： control group, TWH group and TWH ＋ KTHM group. The changes of genital system in all rats were examined after 90 - day feeding. Results Compared with the TWH group, oestrus cycle was normal, estrogen and progestogen level and the weight of reproductive organs increased, the ovary was big, follicle grew well with more corpus luteum and good blood supplying, endometrium was thick with hyperplastic uterine gland, and vaginal epithelium became thick and cornificated in TWH ＋ KTHM group. Conclusion Kidney - tonifying herbal medicine can antagonize the toxic and side effects of Tripterygium Wilfordii on the genital system of female rat.