怡欣乐口服液镇静催眠及抗惊厥作用研究

Experimental Study on Sedative, Hypnotic and Anticonvulsive Actions of Yi Xin Le Oral Liquid

目的研究中药复方制剂怡欣乐口服液(YXL)治疗失眠的作用机理。方法通过YXL对实验小鼠自发活动的影响,对戊巴比妥钠阈下剂量、阈剂量小鼠睡眠时间和对硝酸士的宁致小鼠惊厥的影响,研究YXL镇静、催眠、抗惊厥作用。结果YXL能抑制小鼠自发活动,对小鼠睡眠的影响与戊巴比妥钠有协同作用,有对抗硝酸士的宁致惊厥发作的作用,且剂量越大,作用越明显。结论YXL有明显的镇静、催眠、抗惊厥作用;本实验为YXL的临床运用提供了药效学方面的实验依据。

Objective To investigate the therapeutic mechanism of Chinese medicine of Yi Xin Le oral liquid （YXL） on insomnia. Methods Mice spontaneous activities, mice sleep time induced by sodium pentobarbital in the threshold dose and under the threshold dose and mice convulsion induced by strychnine nitrate were observed to evaluate the sedative, hypnotic and anticonvulsive actions of YXL. Results YXL could restrain the spontaneous movement in mice, had a synergistic action with sodium pentobarbital on mice sleep, and could counteract the convulsive attack induced by strychnine nitrate in a dose - dependent manner. Conclusion YXL has obvious sedative, hypnotic and anticonvulsive actions and this will supply evidence for its clinical usage.