复方甘草酸苷治疗新生儿肝炎疗效观察

Observation on Curative Effect of Compound Glycyrrhizin Injection in the Treatment of Neonatal Hepatitis

目的:观察复方甘草酸苷治疗新生儿肝炎的疗效及安全性。方法:68例新生儿肝炎患儿随机分为治疗组与对照组,分别静脉滴注复方甘草酸苷注射液、生脉注射液,剂量均为3ml/(kg·次),1次/d,连用14d。结果:治疗后治疗组的肝功能指标明显好于对照组(P<0.001或P<0.01);治疗组与对照组的住院时间分别为(17.4±3.1)d、(19.7±3.5)d(P<0.01),治愈率分别为79.4%、58.8%(P<0.05)。结论:复方甘草酸苷治疗新生儿肝炎疗效好、安全。

OBJECTIVE： To observe the curative effect and safety of compound glycyrrhizin injection in the treatment of neonatal hepatitis syndrome（NHS）.METHODS： 68 neonates with NHS were randomly divided into treatment and control group（n = 34） ,undertaking intravenous administration of glycyrrhizin injection and shengmai injection respectively,both at a dose of 3ml/ （kg· d） for 2 weeks consecutively.RESULTS： The liver function in the treatment group after treatment was significantly better than that in the control group（P〈0.001 or P〈0.01） .The length of hospitalization for treatment and control group were（ 17.4 ±3.1）d and （ 19.7 ± 3.5）d, respectively （P 〈 0.01）, while the cure rates were 79.4 % and 58.896, respectively （P〈 0.05）.CONCLUSION ：Glycyrrhizin injection is effective and safe in the treatment of neonatal hepatitis syndrome.