期刊文献+

活化蛋白-1和糖皮质激素受体在慢性阻塞性肺疾病中的作用

原文传递
导出
摘要 慢性阻塞性肺疾病(COPD)以气道慢性炎症为主要特征,糖皮质激素是强有力的抗炎药物,但对COPD的治疗效果不太理想。活化蛋白1和糖皮质激素受体的表达水平及活性状态是影响激素疗效的重要因素,本文针对活化蛋白1和糖皮质激素受体在COPD发病中的作用以及对激素治疗的关系作一综述。
出处 《国际呼吸杂志》 2006年第3期189-191,共3页 International Journal of Respiration
  • 相关文献

参考文献19

  • 1Caramori G,Ito K,Adcock IM.Transcription factors in asthma and COPD.Drugs,2004,7(8):764-770.
  • 2Cosio BG,Torrego A,Adcock IM.Molecular mechanisms of glucocorticoids.Arch Bronconeumol,2005,41 (1):34-41.
  • 3Barnes PJ.Corticosteroid Resistance in Airway Disease.Proc ATS,2004,1 (3):264-268.
  • 4Bobrovnikova-Marjon EV,Marjon PL,Barbash O,et al.Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability:role of nuclear factor-kappaB and activating protein-1.Cancer Res,2004,64(14):4858-4869.
  • 5Barczyk A,Sozanska E,Trzaska M,et al.Decreased levels of myeloperoxidase in induced sputum of patients with COPD after treatment with oral glucocorticoids.Chest,2004,126 (2):389-393.
  • 6Rahman I,MacNee W.Role of transcription factors in inflammatory lung diseases.Thorax,1998,53(7):601-606.
  • 7Brown DM,Donaldson K,Borm PJ,et al.Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles.Am J Physiol Lung Cell Mol Physiol,2004,286 (2):L344-353.
  • 8Woo CH,Lim JH,Kim JH.Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7cells.J Immunol,2004,173(11):6973-6980.
  • 9Aljada A,Ghanim H,Mohanty P,et al.Hydrocortisone suppresses intranuclear activator protein-1 (AP-1) binding activity in mononuclear cells and plasma matrix metalloproteinase-2 and-9 (MMP-2 and MMP-9).J Clin Endocrinol Metab,2001,86(12):5988-5991.
  • 10Korn SH,Thunnissen FB,Wesseling GJ,et al.Glucocorticoid receptor mRNA levels in bronchial epithelial cells of patients with COPD:influence of glucocorticoids.Respir Med,1998,92 (9):1102-1109.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部