益妇宁胶囊对去势高血脂模型大鼠血脂水平的影响

Effects of Yifuning capsule on blood lipids of ovariectomized hyperlipidemia rats

目的:观察益妇宁(YFN)胶囊对去势高血脂大鼠血脂水平的影响。方法:56只SD雌性大鼠随机分为7组:正常组、模型对照组、乙烯雌酚片组、血脂康组、YFN高、中、低剂量组。造模成功后喂高脂饲料并给药3周,测定大鼠体重及肝指数,并用试剂盒检测血脂五项(TC,TG,HDL-C,LDL-C,VLDL)及酶(HP,LPL,总脂酶)的水平。结果:模型组大鼠的体重、肝指数较正常组明显升高(P<0.05),YFN能明显降低去势高脂大鼠血清TG,TC,LDL-C水平(P<0.05),明显升高HP,LPL,总脂酶的水平(P<0.05)。结论:YFN可以改善去势高血脂大鼠血脂水平。

Objective： To observe the effects of Yifuning（YEN） capsule on blood lipids of ovariectomized hyperlipidemia rats. Method：Fifty-six female mature sprague-dawley rats were randomized into 7 groups： normal control group, model control group, diethylstilbestrol tablets （DT） group, Xuezhikang group, YFN high, middle and low dose groups. The ovariectomized rats were fed on high fat diet and administrated with the drugs for 3 weeks, then were killed and estimated body weight, liver index and five items of blood lipid （TC,TG, HDL-C, LDL-C, VLDL） by test kit. Enzyme （such as HP, LDL, and whole lipase） was detected too. Result： The weight and liver index of model control group increased obviously as compared with normal group. YFN could reduce TG, TC, and LDL-C （ P 〈 0.05） of ovariectomized hyperlipidemia rats obviously and increase HP, LDL and whole lipase （ P 〈 0.05） on the other hand. Conclusion： YFN can ameliorate blood lipids of ovariectomized hyperlipidemia rats.