金铁锁总皂苷抗类风湿性关节炎作用及其作用机制研究

Effects and mechanism of total saponins of Psammosilene tunicoids against rheumatoid arthritis

目的:考察金铁锁总皂苷(TSPT)抗类风湿性关节炎(RA)的药理作用及作用机制。方法:建立佐剂性关节炎(AA)动物模型,观察TSPT对AA大鼠足肿胀、关节炎指数及炎性组织液中促炎细胞因子IL-1β,TNF-α水平的影响。结果:TSPT能有效抑制关节肿胀率及关节指数,降低AA大鼠炎性组织液中促炎细胞因子L-1β,TNF-α的水平。结论:TSPT具有良好的抗RA作用,其作用机制与抑制促炎细胞因子L-1β,TNF-α的水平有关。

Objective： To observe the antiarthritic effects and the possible mechanism of total saponins of Psammosilene tunicoids （TSPT）against rheumatoid arthritis（RA）. Method： After establishing AA rat model, the TSPTS antiarthritic effects and mechanism against RA were studied through observing the changes of ankle swelling, arthritis index and levels of IL-10β and TNF-α after medication. Result： TSPT could effectively inhibits articular swelling, decrease arthritis index and regulate down the content of IL-1β and TNF-α in the inflammatory tissue soak of AA rats. Coonclusion： TSPT has good antiarthritic effects and the possible mechanism may be related to its down-regulation of IL-1β and TNF-α.