大肠癌旁粘膜CEA及GST＿π抗原表达

CEA and GST_π antigen experssion in transitional mucosa adjacent to colorectal carcinoma

目的探讨大肠癌旁移行粘膜胚胎性癌抗原表达的意义。方法用免疫组化ＰＡＰ法测ＣＥＡ和免疫金银法测谷胱苷肽Ｓ＿转移酶（ＧＳＴ＿π）在５２例大肠癌，３４例癌旁粘膜以及３５例正常粘膜组织中的抗原表达情况。结果移行粘膜ＣＥＡ和ＧＳＴ＿π的阳性表达率分别为３２．８％和４４．１％，与正常粘膜（阳性率分别为５．７％和１１．８％）和大肠癌（阳性率分别为８６．５％和９６．１％）相比，均有显著性差异（Ｐ＜０．０５）。结论移行粘膜有去分化趋势。

AIMS To study the expression of oncofetal antigens CEA and GST_π in transitional mucosa(TM) and its significance. METHODS CEA and the placental form of glutathione S_transferase(GST_π) were detected with PAP and immunogold silver staining techqinues respectively in 52 cases of large intestinal adenocarcinoma, 34 cases of TM and 35 casees of normal mucosa. RESULTS The positivity rates of CEA and GST_π were significantly higher in TM (32.8% and 44.1%) than those in normal mucosa(5.7% and 11.8%), but significantly lower than those of the carcinoma(86.5% and 96.1%, P<0.05), with dedifferentiation tendency of TM. CONCLUSIONS TM may give early prediction of maligant changes.