原发性肝癌患者血清甲状腺激素变化

Changes of serum thyroid hormones in patients with primary hepatic carcinoma

目的观察原发性肝癌（ＰＨＣ）患者血清甲状腺激素的变化。方法应用放射免疫法（ＲＩＡ）检测２４例ＰＨＣ患者的血清Ｔ３，Ｔ４，ＴＳＨ和ｒＴ３，并以２４例健康成人作对照。结果ＰＨＣ组血清Ｔ３为１．６０±０．１４ｎｍｏｌ／Ｌ，而对照组为２．３７±０．０８ｎｍｏｌ／Ｌ（Ｐ＜０．００１）。ＰＨＣ切除组血清Ｔ３，Ｔ４和ｒＴ３分别为１．９４±０．１６ｎｍｏｌ／Ｌ，１３４．３４±１１．４９ｎｍｏｌ／Ｌ和２．６１±０．３９；而ＰＣＨ未切除组分别为１．２２±０．１７ｎｍｏｌ／Ｌ（Ｐ＜０．０５），１０４．０１±７．２４ｎｍｏｌ／Ｌ（Ｐ＜０．０５）和１．３５±０．３６（Ｐ＜０．０５）。结论ＰＨＣ患者血清Ｔ３降低，晚期患者出现血清Ｔ４降低和Ｔ３／ｒＴ３比值降低。

AIMS\ To study the changes of serum throid hormones in patients with primary hepatic carcinoma(PHC). METHODS\ The concentrations of serum 3,5,3' triiodothyronice (T 3), thyroxin(T 4), thyroid_stimulating hormone(TSH) and 3, 3', 5' triiodothyronime (rT 3) in 24 PHC patients were determined by radioimminoassay (RIA). Twenty_four healthy adult subjects were controlled. RESULTS\ The concentrations of serum T 3 in PHC group was 1.6±0.14nmol/L, and that in the control was 2.37±0.08nmol/L(P<0.001). In PHC patients, the concentrations of serum T 3, T 4 and T 3/rT 3 ratio in the resection group were 1.94±0.16nmol/L, 134.34±11.49nmol/L and 2.61±0.39; but those in late patients without resection were 1.22±0.17nmol/L(P<0.05), 104.01±7.24nmol/L(P<0.05) and 1.35±0.36(P<0.05). CONCLUSIONS\ The concentrations of serum T 3 in PHC patients decrease. In late PHC patients, the concentrations of serum T 4 and T 3/rT 3 ratio decrease.