凝血因子VII在肾病综合征中的临床意义

A Preliminary Investigation of the Clinical Value of Coagulation Factor VII In Nephrotic Syndrome

为了探讨凝血因子VII在原发性肾病综合征血栓栓塞性疾病发生发展中的作用，本文检测了26例。肾病综合征患者血浆激活的因子VII水平（FVIIa）、血浆因子VII活性（FVIIc），血浆因子VII酶原激活（FVIIAg）水平，24h尿蛋白定量，血肌酐及甘油三酯、胆固醇的水平，并与26例健康人进行了对照。结果表明：肾病综合征患者血浆激活的因子VII水平（FVIIa），血浆因子VII活性（FVIIc）．血浆因子VII酶原激活（FVIIAg）水平明显高于对照组，差异均具有显著性（P〈0.05），且与24h尿蛋白定量，血肌酐、甘油三酯、胆固醇的水平呈正相关。提示：凝血因子VII异常可能是肾病综合征惠者血栓栓塞并发症发生的潜在因素，如对肾病综合征患者通过调控因子VII水平及活性，可能有助于缓解其高凝状态，减少其血栓栓塞并发症的发生率及死亡率。

To investigate the clinical value of Coagulation Factor VII in nephrotic syndrome, detect the level of FVIIa, FVIIc, FVIIAg, 24 hours proteinuria,bloodCR TG CHL with 26 case patients and compare with 26 normal cases. The results showed that the level of FVIIa,FVIIc ,FVIIAg were increased significantly in nephrotic syndrome. There was also a statistically significant difference between experiment group and control group. FVIIa,FVIIc ,FVIIAg had a positive relation with 24 hours proteinuria, blood CK, TG, CHL. This study suggests that the level of FVIIa,FVIIc ,FVIIAg may be an important reference parameter in evaluating the effect on the thrombotic complications of nephrotic syndrome.To adjust the level and activity of FVII in nephrotic syndrome patients may remissiom hypercoagulable state,to reduce the incidence and death rate of complication of thromboembolus.